In the first large-scale human study of the chemical, some found with bisphenol A in their urine had more than double the normal risk of heart disease and diabetes.
The first large-scale human study of a chemical used to make plastic baby bottles, aluminum can linings and myriad other common products found double the risk of cardiovascular disease, diabetes and liver problems in people with the highest concentrations in their urine, British researchers reported Tuesday.
The findings confirm earlier results obtained in animals, increasing pressure on the U.S. Food and Drug Administration to limit use of the chemical bisphenol A, or BPA.
The compound is the primary ingredient of polycarbonate plastics, which are found in a wide variety of modern goods, including DVDs, reusable food storage containers, drinking bottles and eyeglass lenses.
There have been growing concerns about its safety as studies in rodents have linked it to diabetes, brain damage, developmental abnormalities, precancerous changes in the prostate and breast, and a variety of other health problems.
Many scientists believe it can act like the hormone estrogen, and animal studies have linked it with breast, prostate and reproductive system problems and some cancers.
About 7 billion pounds of the chemical are produced worldwide each year, and studies by the federal Centers for Disease Control and Prevention have found that 93% of Americans have detectable levels in their urine.